Enzyme which Regulates Metabolism of Fats is Discovered

Metabolism is a set of chemical reactions necessary for sustaining of life. It consists of two parts, namely, catabolism and anabolism. Researchers from the Baylor College of Medicine have discovered very important enzyme which regulates metabolism.

Inhibiting the actions of this enzyme can prove to be in the best interest of the Americans who are almost addicted to Western diet. The results of the finding are published in the January 2011 issue of the Journal Cell Metabolism, a Cell press publication.

How the Enzyme AMPK-SRC-2 Regulates Metabolism?

  • Catabolism involves breaking down of organic matter to gather energy for carrying out vital processes.
  • Anabolism uses energy for construction of cellular components like nucleic acid and proteins.
  • In both the processes, the energy is used in the form of energy currency ATP.
  • The discovered enzyme is known to be an energy sensor which initiates a series of events leading to increased fat absorption when energy levels drop down in cells.
  • It also regulates the expenditure of ATP by ensuring that it is consumed less and produced more.
  • The enzyme is known to drive appetite in the body too. Enzymes are naturally produced chemicals which influence the rate of different chemical reactions.

Latest Knowledge on How AMPK-SRC-2 Enzyme Regulates Metabolism:

  • The present study has found that this enzyme plays a vital role in the absorption of fat by activating a master gene SRC-2.
  • This gene in turn monitors switching on and off of other genes which regulate production, separation and delivery of bile juice (required for fat absorption) from the gall bladder to the intestine.
  • Experimental mice lacking this gene have impaired fat absorption confirming the role of the enzyme in absorption and absorption of fat.
  • The study’s major discovery is

    the role of this enzyme in releasing stored glucose energy when there is not enough fat in the body to meet energy requirements


  • But, this is the situation of the past when fat was not excessively consumed through diet. In the recent times, all our foods are stuffed with excess fat.
  • An interesting aspect of the glucose releasing ability of the enzyme is that this process takes place on daily basis irrespective of the fat levels in the body.


As obesity is all about proper absorption and storage of fat in the body, inhibition of the SRC-2 gene can provide a novel treatment option for this physical disorder. Future research of this study is aimed at finding out such an inhibitor of the SRC-2 gene which regulates metabolism in obese people as its treatment mechanism.

Leave a reply

Your email address will not be published. Required fields are marked *