Obesity

New Genes Linked To Obesity

Two different studies were conducted which had identified nearly 18 genes that  are linked to overall obesity. There are also 13 other influential genes which decide whether your weight will go to your belly or to your thighs. The details of the study conducted are discussed in the article below.

Details of The Study Conducted:

The first study was conducted on 123,865 people and recognized 18 new regions of genes which are associated with the BMI (Body Mass Index) of the body. The genes present in this region affect the appetite control while others play a major role in metabolism. There are also other genes which had a greater risk of obesity on the person. The study concluded that those individuals who had 38 or more BMI- associated genes weigh 15 – 20 pounds more or on average as compared to those who had less than 22 genes. These variants contribute less change in body weight, but there are several other environmental and genetic changes which also play a major role in obesity.

The second study which was conducted on 77,167 people identified genes which are associated with hip-to-waist ratio, which is used for measuring the distribution of fat in the body. The fat in the belly is considered as a risk factor for type 2 diabetes and also for heart disease. The fat which is stored in hip and thighs plays a protective role against high blood pressure and diabetes.

Missing Genes Responsible For obesity:

Some research studies have concluded that there is an entire set of genes in DNA that has been found in morbid people which can play an important role in obesity. The conducted research found that nearly 100 people lacked the set of nearly 30 genes in DNA which was not there in people with normal weight. But there is still a view that environmental conditions and unhealthy eating habits can become genetic which can result in obesity.

References

Longitudinal Replication Studies of GWAS Risk SNPs Influencing Body Mass Index over the Course of Childhood and Adulthood.
Mei H, Chen W, Jiang F, He J, Srinivasan S, Smith EN, Schork N, Murray S, Berenson GS.
PLoS One. 2012;7(2):e31470. Epub 2012 Feb 15.
PMID: 22355368 [PubMed – in process

Meta-analysis identifies common variants associated with body mass index in east Asians.
Wen W, Cho YS, Zheng W, Dorajoo R, Kato N, Qi L, Chen CH, Delahanty RJ, Okada Y, Tabara Y, Gu D, Zhu D, Haiman CA, Mo Z, Gao YT, Saw SM, Go MJ, Takeuchi F, Chang LC, Kokubo Y, Liang J, Hao M, Le Marchand L, Zhang Y, Hu Y, Wong TY, Long J, Han BG, Kubo M, Yamamoto K, Su MH, Miki T, Henderson BE, Song H, Tan A, He J, Ng DP, Cai Q, Tsunoda T, Tsai FJ, Iwai N, Chen GK, Shi J, Xu J, Sim X, Xiang YB, Maeda S, Ong RT, Li C, Nakamura Y, Aung T, Kamatani N, Liu JJ, Lu W, Yokota M, Seielstad M, Fann CS; The Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Wu JY, Lee JY, Hu FB, Tanaka T, Tai ES, Shu XO.
Nat Genet. 2012 Feb 19. doi: 10.1038/ng.1087. [Epub ahead of print]
PMID: 22344219 [PubMed – as supplied by publisher]

Caro JF, Sinha MK, Kolaczynski JW, Zhang PL, Considine RV
Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.carojose@lilly.com

The Human Obesity Gene Map: The 2005 Update
Tuomo Rankinen*, Aamir Zuberi†, Yvon C. Chagnon‡, S. John Weisnagel§, George Argyropoulos¶, Brandon Walts*, Louis Pérusse§ and Claude Bouchard*,*
1. *Human Genomics, Pennington Biomedical Research Center, Baton Rouge, Louisiana
2. †Functional Genomics, Pennington Biomedical Research Center, Baton Rouge, Louisiana
3. ¶Energy Balance Genomics Laboratories, Pennington Biomedical Research Center, Baton Rouge, Louisiana
4. ‡Psychiatric Genetic Unit, Laval University Robert-Giffard Research Center, Quebec, Canada
5. §Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte-Foy, Quebec, Canada.
Correspondence: Claude Bouchard Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808-4124. E-mail:
Bouchac@PBRC.edu, http://www.nature.com/oby/journal/v14/n4/abs/oby200671a.html

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